Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis

OBJECTIVES: Integrin α1β1 protects against osteoarthritis (OA) when it is upregulated in the superficial zone of cartilage in the early stages of disease. However, the mechanism behind this protection is unknown. Integrin α1β1 moderates transforming growth factor β receptor II (TGFBR2) signalling, a...

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Detalles Bibliográficos
Autores principales: St Amant, Jennifer, Michaud, Jana, Hinds, Daniel, Coyle, Madison, Pozzi, Ambra, Clark, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
ORIGINAL PAPER
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462827/
https://www.ncbi.nlm.nih.gov/pubmed/37649532
http://dx.doi.org/10.1016/j.ocarto.2023.100399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462827/
https://www.ncbi.nlm.nih.gov/pubmed/37649532
http://dx.doi.org/10.1016/j.ocarto.2023.100399

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