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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
Myeloid hematopoiesis is a finely controlled consecutive developmental process, which is essential to maintain peripheral innate immune homeostasis. Herein, we found that Rictor deletion caused the remarkable reduction of granulocyte-monocyte progenitors (GMPs), monocytes, and macrophages, while the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462862/ https://www.ncbi.nlm.nih.gov/pubmed/37649699 http://dx.doi.org/10.1016/j.isci.2023.107540 |