Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, in silico and preliminary kinetic studies

In this study, we investigated the conjugation of theophylline with different compounds of natural origin hoping to construct new hybrids with dual activity against cholinergic and inflammatory pathways as potential agents for the treatment of Alzheimer's disease (AD). Out of 28 tested hybrids,...

Descripción completa

Detalles Bibliográficos
Autores principales: Elgazar, Abdullah A., El-Domany, Ramadan A., Eldehna, Wagdy M., Badria, Farid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463010/
https://www.ncbi.nlm.nih.gov/pubmed/37649576
http://dx.doi.org/10.1039/d3ra04867e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463010/
https://www.ncbi.nlm.nih.gov/pubmed/37649576
http://dx.doi.org/10.1039/d3ra04867e

Ejemplares similares