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An unstructured proteasome inhibitor comes into focus

The inhibitory mechanism of an intrinsically disordered proteasome inhibitor identified over 30 years ago has finally been revealed by cryo-electron microscopy by Hsu et al. in a recent report in the Journal of Biological Chemistry. The structure, coupled with biochemical and cell-based experiments,...

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Detalles Bibliográficos
Autores principales: Nemec, Antonia A., Tomko, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463253/
https://www.ncbi.nlm.nih.gov/pubmed/37562568
http://dx.doi.org/10.1016/j.jbc.2023.105145