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Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases

BACKGROUND: Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites; regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial...

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Detalles Bibliográficos
Autores principales: Zhou, Qi, Tao, Xufeng, Guo, Fangyue, Wu, Yu, Deng, Dawei, Lv, Linlin, Dong, Deshi, Shang, Dong, Xiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463520/
https://www.ncbi.nlm.nih.gov/pubmed/37635214
http://dx.doi.org/10.1186/s12916-023-02997-2