Cargando…

Pimobendan prevents cardiac dysfunction, mitigates cardiac mitochondrial dysfunction, and preserves myocyte ultrastructure in a rat model of mitral regurgitation

BACKGROUND: Pimobendan has been proven to delay the onset of congestive heart failure (CHF) in dogs with mitral regurgitation (MR); however, molecular underlying mechanisms have not been fully elucidated. This study aimed to investigate (1) the effects of pimobendan on cardiac function, cardiac mito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boonpala, Pakit, Saengklub, Nakkawee, Srikam, Sirinapa, Ji-au, Wilawan, Panyasing, Yaowalak, Kumphune, Sarawut, Kijtawornrat, Anusak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463781/ https://www.ncbi.nlm.nih.gov/pubmed/37612694 http://dx.doi.org/10.1186/s12917-023-03693-2

Ejemplares similares

Sacubitril/valsartan mitigates cardiac remodeling, systolic dysfunction, and preserves mitochondrial quality in a rat model of mitral regurgitation
por: Tantisuwat, Lalida, et al.
Publicado: (2023)

Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs
por: Pichayapaiboon, Poonavit, et al.
Publicado: (2021)

Impact of a combination of pimobendan, furosemide, and enalapril on heart rate variability in naturally occurring, symptomatic, myxomatous mitral valve degeneration dogs
por: Pirintr, Prapawadee, et al.
Publicado: (2023)

Preliminary Bioequivalence of an Oral Pimobendan Solution Formulation with Reference Solution Formulation in Beagle Dogs
por: Saengklub, Nakkawee, et al.
Publicado: (2022)

Long-term effect of sildenafil on echocardiographic parameters in dogs with asymptomatic myxomatous mitral valve degeneration
por: KIJTAWORNRAT, Anusak, et al.
Publicado: (2017)

Acute effects of intravenous dronedarone on electrocardiograms, hemodynamics and cardiac functions in anesthetized dogs
por: SAENGKLUB, Nakkawee, et al.
Publicado: (2015)

Short-term effects of oral dronedarone administration on cardiac function, blood pressure and electrocardiogram in conscious telemetry dogs
por: SAENGKLUB, Nakkawee, et al.
Publicado: (2016)

Sildenafil improves heart rate variability in dogs with asymptomatic myxomatous mitral valve degeneration
por: PIRINTR, Prapawadee, et al.
Publicado: (2017)

Short-Term Effects of Sacubitril/valsartan on Echocardiographic Parameters in Dogs With Symptomatic Myxomatous Mitral Valve Disease
por: Saengklub, Nakkawee, et al.
Publicado: (2021)

Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation
por: Saengklub, Nakkawee, et al.
Publicado: (2017)

Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury
por: Mongkolpathumrat, Podsawee, et al.
Publicado: (2022)

Acute effect of ivabradine on heart rate and myocardial oxygen consumption in dogs with asymptomatic mitral valve degeneration
por: Pirintr, Prapawadee, et al.
Publicado: (2018)

Anti-Protease Activity Deficient Secretory Leukocyte Protease Inhibitor (SLPI) Exerts Cardioprotective Effect against Myocardial Ischaemia/Reperfusion
por: Mongkolpathumrat, Podsawee, et al.
Publicado: (2022)

Post-Ischemic Treatment of Recombinant Human Secretory Leukocyte Protease Inhibitor (rhSLPI) Reduced Myocardial Ischemia/Reperfusion Injury
por: Mongkolpathumrat, Podsawee, et al.
Publicado: (2021)

Linking metabolic and contractile dysfunction in aged cardiac myocytes
por: Barton, Gregory P., et al.
Publicado: (2017)

Effects of Chronic Mild Stress on Cardiac Autonomic Activity, Cardiac Structure and Renin–Angiotensin–Aldosterone System in Male Rats
por: Bangsumruaj, Janpen, et al.
Publicado: (2022)

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
por: Jin, Huiling, et al.
Publicado: (2016)

Comparative effects of amiodarone and dronedarone treatments on cardiac function in a rabbit model
por: Boonhoh, Worakan, et al.
Publicado: (2019)

Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes
por: He, Quan, et al.
Publicado: (2014)

Correction to: Epac activation inhibits IL-6-induced cardiac myocyte dysfunction
por: Jin, Huiling, et al.
Publicado: (2019)

Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats
por: Sanit, Jantira, et al.
Publicado: (2019)

Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality
por: Fisher, Joseph B., et al.
Publicado: (2016)

Beneficial Effect of Pimobendan for Severe Heart Failure Due to Transthyretin Cardiac Amyloidosis
por: Okamoto, Nao, et al.
Publicado: (2019)

MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction
por: Tony, Hasahya, et al.
Publicado: (2015)

Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation‐Induced Myocardial Dysfunction
por: Lin, Yu‐Wen, et al.
Publicado: (2021)

Pharmacokinetics of Pimobendan and Its Metabolite O-Desmethyl-Pimobendan Following Rectal Administration to Healthy Dogs
por: Her, Jiwoong, et al.
Publicado: (2020)

Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats
por: Seenak, Porrnthanate, et al.
Publicado: (2021)

Comment on “MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction”
por: Oliveira-Carvalho, Vagner, et al.
Publicado: (2016)

Cardiac T1 mapping enables risk prediction of LV dysfunction after surgery for aortic regurgitation
por: Sinn, Martin, et al.
Publicado: (2023)

Redox signaling in cardiac myocytes
por: Santos, Celio X.C., et al.
Publicado: (2011)

Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia
por: Law, Michelle L., et al.
Publicado: (2021)

Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition
por: Cohen, Charles D., et al.
Publicado: (2021)

Dysfunction of microtubules induces cardiac dysfunction
por: Kitakaze, Masafumi
Publicado: (2018)

Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation
por: Truong, Vien T., et al.
Publicado: (2021)

The pacemaker current in cardiac Purkinje myocytes
Publicado: (1995)

Epigenetic regulation of cardiac myocyte differentiation(†)
por: Oyama, Kyohei, et al.
Publicado: (2014)

Signaling Pathways in Cardiac Myocyte Apoptosis
por: Xia, Peng, et al.
Publicado: (2016)

Biology of the cardiac myocyte in heart disease
por: Peter, Angela K., et al.
Publicado: (2016)

Nanomaterials for Cardiac Myocyte Tissue Engineering
por: Amezcua, Rodolfo, et al.
Publicado: (2016)

Frequency-dependent signaling in cardiac myocytes
por: Haftbaradaran Esfahani, Payam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bi87i2bev8i5k3r45lohidjrph