Cargando…

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis

BACKGROUND: The accumulation of α-synuclein (α-syn), an essential step in PD development and progression, is observed not only in neurons but also in glia, including astrocytes. The mechanisms regulating astrocytic α-syn level and aggregation remain unclear. More recently, it has been demonstrated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Pan, Lan, Guoyu, Xu, Bin, Yu, Zhenwei, Tian, Chen, Lei, Xia, Meissner, Wassilios G., Feng, Tao, Yang, Ying, Zhang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463943/ https://www.ncbi.nlm.nih.gov/pubmed/37620916 http://dx.doi.org/10.1186/s40035-023-00372-y

Ejemplares similares

α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson’s disease
por: Liu, Zongran, et al.
Publicado: (2022)

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease
por: Chung, Chen-Chih, et al.
Publicado: (2021)

Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson’s disease pathogenesis
por: Sheng, Lifu, et al.
Publicado: (2020)

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
por: Kunadt, Marcel, et al.
Publicado: (2015)

Therapeutic functions of astrocytes to treat α-synuclein pathology in Parkinson’s disease
por: Yang, Yunseon, et al.
Publicado: (2022)

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?
por: Faustini, Gaia, et al.
Publicado: (2017)

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
por: Han, Deqiang, et al.
Publicado: (2020)

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
por: Baena-Montes, Jara M., et al.
Publicado: (2021)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
por: Smith, Jessica K., et al.
Publicado: (2023)

Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
por: Filippini, Alice, et al.
Publicado: (2020)

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
por: Gu, Xing-Long, et al.
Publicado: (2010)

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease
por: Yan, Shijun, et al.
Publicado: (2023)

Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease
por: Castillo-Gonzalez, Juan Antonio, et al.
Publicado: (2017)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
por: Ikenaka, Kensuke, et al.
Publicado: (2019)

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
por: Butkovich, Laura M., et al.
Publicado: (2018)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
por: Gustafsson, Gabriel, et al.
Publicado: (2018)

Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers
por: Yan, Shijun, et al.
Publicado: (2023)

Astrocyte dysfunction in Parkinson's disease: from the perspectives of transmitted α-synuclein and genetic modulation
por: Wang, Changjing, et al.
Publicado: (2021)

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease
por: Basurco, Leyre, et al.
Publicado: (2022)

Poly (ADP-Ribose) and α–synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity
por: Lucien, Fabrice, et al.
Publicado: (2022)

Plasma extracellular vesicle tau, β-amyloid, and α-synuclein and the progression of Parkinson’s disease: a follow-up study
por: Chan, Lung, et al.
Publicado: (2023)

The direct and indirect effects of α-synuclein on microtubule stability in the pathogenesis of Parkinson’s disease
por: Carnwath, Tom, et al.
Publicado: (2018)

Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila
por: Liu, Wei, et al.
Publicado: (2022)

Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson’s disease pathogenesis
por: Basu, Sambuddha, et al.
Publicado: (2023)

TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression
por: Zhang, Xin, et al.
Publicado: (2021)

A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition
por: Taha, Hash Brown, et al.
Publicado: (2022)

The Synucleins and the Astrocyte
por: Myers, Abigail J., et al.
Publicado: (2023)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
por: Du, Xiao-yu, et al.
Publicado: (2020)

Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease
por: Basu, Sambuddha, et al.
Publicado: (2015)

Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective
por: Yi, Shuanglong, et al.
Publicado: (2022)

An intact membrane is essential for small extracellular vesicle‐induced modulation of α‐synuclein fibrillization
por: Ugalde, Cathryn L., et al.
Publicado: (2020)

Extracellular Vesicles Taken up by Astrocytes
por: Ogaki, Ari, et al.
Publicado: (2021)

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
por: Laferrière, Florent, et al.
Publicado: (2020)

Erythrocytic α-Synuclein Species for Parkinson’s Disease Diagnosis and the Correlations With Clinical Characteristics
por: Yu, Zhenwei, et al.
Publicado: (2022)

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase
por: Wang, Kaizhe, et al.
Publicado: (2017)

Extracellular vesicles participate in the pathogenesis of sepsis
por: Tian, Chang, et al.
Publicado: (2022)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
por: Li, Puyu, et al.
Publicado: (2021)

Cell Responses to Extracellular α-Synuclein
por: Surguchev, Alexei A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5rarc1r146ufeg9jb1f41jnsuu