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Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species

BACKGROUND: Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of “early-life-pain” (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin (Avil) promoter, which drives expression of...

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Detalles Bibliográficos
Autores principales: Vogel, Alexandra, Ueberbach, Timo, Wilken-Schmitz, Annett, Hahnefeld, Lisa, Franck, Luisa, Weyer, Marc-Philipp, Jungenitz, Tassilo, Schmid, Tobias, Buchmann, Giulia, Freudenberg, Florian, Brandes, Ralf P., Gurke, Robert, Schwarzacher, Stephan W., Geisslinger, Gerd, Mittmann, Thomas, Tegeder, Irmgard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463951/
https://www.ncbi.nlm.nih.gov/pubmed/37635256
http://dx.doi.org/10.1186/s13578-023-01106-3