Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity

BACKGROUND: Novel precision medicine therapeutics target increasingly granular, genomically-defined populations. Rare sub-groups make it challenging to study within a clinical trial or single real-world data (RWD) source; therefore, pooling from disparate sources of RWD may be required for feasibili...

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Detalles Bibliográficos
Autores principales: Backenroth, Daniel, Royce, Trevor, Pinheiro, Jose, Samant, Meghna, Humblet, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464044/
https://www.ncbi.nlm.nih.gov/pubmed/37620758
http://dx.doi.org/10.1186/s12874-023-02002-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464044/
https://www.ncbi.nlm.nih.gov/pubmed/37620758
http://dx.doi.org/10.1186/s12874-023-02002-7

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