Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia

Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML). However, MRD cannot be detected in many patients using current methods. We developed a highly sensitive 5-hydroxymethylcytosine (5hmC) signature in cell-free DNA by analyzing 115 AML patients and 86 controls...

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Detalles Bibliográficos
Autores principales: Shao, Jianming, Shah, Shilpan, Ganguly, Siddhartha, Zu, Youli, He, Chuan, Li, Zejuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464230/
https://www.ncbi.nlm.nih.gov/pubmed/37620919
http://dx.doi.org/10.1186/s13148-023-01547-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464230/
https://www.ncbi.nlm.nih.gov/pubmed/37620919
http://dx.doi.org/10.1186/s13148-023-01547-0

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