GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice

BACKGROUND: Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing apoptotic neuronal debris, allowing for repair and regeneration. Our previous research has shown that gasdermin D (GSD...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoxia, Cao, Qingqing, Guo, Yi, He, Jingchuan, Xu, Demei, Lin, Aolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464294/
https://www.ncbi.nlm.nih.gov/pubmed/37612735
http://dx.doi.org/10.1186/s12974-023-02876-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464294/
https://www.ncbi.nlm.nih.gov/pubmed/37612735
http://dx.doi.org/10.1186/s12974-023-02876-w

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