Cargando…

GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice

BACKGROUND: Temporal lobe epilepsy (TLE) is often characterized pathologically by severe neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing apoptotic neuronal debris, allowing for repair and regeneration. Our previous research has shown that gasdermin D (GSD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xiaoxia, Cao, Qingqing, Guo, Yi, He, Jingchuan, Xu, Demei, Lin, Aolei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464294/ https://www.ncbi.nlm.nih.gov/pubmed/37612735 http://dx.doi.org/10.1186/s12974-023-02876-w

Ejemplares similares

Intestinal Klebsiella pneumoniae infection enhances susceptibility to epileptic seizure which can be reduced by microglia activation
por: Lin, Peijia, et al.
Publicado: (2021)

The Dilemma of the Chicken or the Egg—What Appears First in TLE—Seizures or Morphometric Changes in the Temporal Lobe?
por: Szaflarski, Jerzy P.
Publicado: (2019)

Phagocytic microglia in development: Are they what they eat?
por: VanRyzin, Jonathan W.
Publicado: (2021)

TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease
por: Zhang, Xue, et al.
Publicado: (2022)

Phagocytic microglia and macrophages in brain injury and repair
por: Yu, Fang, et al.
Publicado: (2022)

Phagocytic astrocytes: Emerging from the shadows of microglia
por: Konishi, Hiroyuki, et al.
Publicado: (2022)

Thalamic functional connectivity predicts seizure laterality in individual TLE patients: Application of a biomarker development strategy
por: Barron, Daniel S., et al.
Publicado: (2014)

Minocycline Attenuates Microglia/Macrophage Phagocytic Activity and Inhibits SAH-Induced Neuronal Cell Death and Inflammation
por: Blecharz-Lang, Kinga G., et al.
Publicado: (2022)

TLE1 function and therapeutic potential in cancer
por: Yuan, Da, et al.
Publicado: (2016)

Review: the role of GSDMD in sepsis
por: Shao, Ruifei, et al.
Publicado: (2022)

Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia
por: Qian, Shuang, et al.
Publicado: (2022)

Microglia display modest phagocytic capacity for extracellular tau oligomers
por: Majerova, Petra, et al.
Publicado: (2014)

Phagocytic glioblastoma-associated microglia and macrophages populate invading pseudopalisades
por: Saavedra-López, Elena, et al.
Publicado: (2019)

Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury
por: Du, Hao, et al.
Publicado: (2022)

Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs
por: Hu, Shunlian, et al.
Publicado: (2022)

Expression of Groucho/TLE proteins during pancreas development
por: Hoffman, Brad G, et al.
Publicado: (2008)

Beating the Odds: Intact Neuropsychological Functioning despite TLE
por: Nehra, Ashima, et al.
Publicado: (2014)

Volumetric and structural connectivity abnormalities co-localise in TLE
por: Horsley, Jonathan J., et al.
Publicado: (2022)

Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia
por: Wang, Kankai, et al.
Publicado: (2020)

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage
por: Gu, Lingui, et al.
Publicado: (2022)

'MRI-negative PET-positive' temporal lobe epilepsy (TLE) and mesial TLE differ with quantitative MRI and PET: a case control study
por: Carne, Ross P, et al.
Publicado: (2007)

Grg3/TLE3 and Grg1/TLE1 Induce Monohormonal Pancreatic β-Cells While Repressing α-Cell Functions
por: Metzger, David E., et al.
Publicado: (2014)

The Regulation and Modification of GSDMD Signaling in Diseases
por: Li, Zihao, et al.
Publicado: (2022)

Microglia after Seizures and in Epilepsy
por: Hiragi, Toshimitsu, et al.
Publicado: (2018)

Galectin-3 (MAC-2) Controls Microglia Phenotype Whether Amoeboid and Phagocytic or Branched and Non-phagocytic by Regulating the Cytoskeleton
por: Reichert, Fanny, et al.
Publicado: (2019)

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus
por: Matsuda, Taito, et al.
Publicado: (2015)

p27(kip1) Modulates the Morphology and Phagocytic Activity of Microglia
por: Beeken, Jolien, et al.
Publicado: (2022)

Downregulation of CD40L–CD40 attenuates seizure susceptibility and severity of seizures
por: Pototskiy, Esther, et al.
Publicado: (2021)

Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3/GSDMD pathway in pulmonary bronchial epithelia
por: Wu, Dong-Ming, et al.
Publicado: (2022)

TLE3 as a candidate biomarker of response to taxane therapy
por: Kulkarni, Swati A, et al.
Publicado: (2009)

DTI-based response-driven modeling of mTLE laterality()
por: Nazem-Zadeh, Mohammad-Reza, et al.
Publicado: (2015)

ZDHHC8 critically regulates seizure susceptibility in epilepsy
por: Yang, Qin, et al.
Publicado: (2018)

Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum1,2,3
por: Perez-Pouchoulen, Miguel, et al.
Publicado: (2015)

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
por: Colombo, Alessio, et al.
Publicado: (2021)

p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
por: Perea, Juan R., et al.
Publicado: (2022)

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/Caspase-1/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson’s Disease
por: Rui, Wenjuan, et al.
Publicado: (2020)

Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes—Activation and Age-Related Effects
por: Rangaraju, Srikant, et al.
Publicado: (2018)

GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
por: Sonny, Sarah, et al.
Publicado: (2023)

Immunohistochemical validation of TLE1, a novel marker, for synovial sarcomas
por: Rekhi, Bharat, et al.
Publicado: (2012)

Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth
por: Verginelli, Federica, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_b108a0burdupmou54hj01ae2v3