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Pathogenic mutation hotspots in protein kinase domain structure

Control of eukaryotic cellular function is heavily reliant on the phosphorylation of proteins at specific amino acid residues, such as serine, threonine, tyrosine, and histidine. Protein kinases that are responsible for this process comprise one of the largest families of evolutionarily related prot...

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Detalles Bibliográficos
Autores principales: Medvedev, Kirill E., Schaeffer, R. Dustin, Pei, Jimin, Grishin, Nick V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464295/
https://www.ncbi.nlm.nih.gov/pubmed/37572333
http://dx.doi.org/10.1002/pro.4750