The inactive X chromosome accumulates widespread epigenetic variability with age

BACKGROUND: Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence, age-related disruption of X-chromosome inactivation (XCI) may contribute to t...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yunfeng, Sinke, Lucy, Jonkman, Thomas H., Slieker, Roderick C., van Zwet, Erik W., Daxinger, Lucia, Heijmans, Bastiaan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464315/
https://www.ncbi.nlm.nih.gov/pubmed/37626340
http://dx.doi.org/10.1186/s13148-023-01549-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464315/
https://www.ncbi.nlm.nih.gov/pubmed/37626340
http://dx.doi.org/10.1186/s13148-023-01549-y

Ejemplares similares