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The inactive X chromosome accumulates widespread epigenetic variability with age

BACKGROUND: Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence, age-related disruption of X-chromosome inactivation (XCI) may contribute to t...

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Detalles Bibliográficos
Autores principales:	Liu, Yunfeng, Sinke, Lucy, Jonkman, Thomas H., Slieker, Roderick C., van Zwet, Erik W., Daxinger, Lucia, Heijmans, Bastiaan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464315/ https://www.ncbi.nlm.nih.gov/pubmed/37626340 http://dx.doi.org/10.1186/s13148-023-01549-y

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