Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy

The calcium-responsive phosphatase, calcineurin, senses changes in Ca(2+) concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent transcription factor CRZ1 triggered the formation of...

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Detalles Bibliográficos
Autores principales: Chawla, Srishti, Ahmadpour, Doryaneh, Schneider, Kara L., Kumar, Navinder, Fischbach, Arthur, Molin, Mikael, Nystrom, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464345/
https://www.ncbi.nlm.nih.gov/pubmed/37620860
http://dx.doi.org/10.1186/s12964-023-01242-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464345/
https://www.ncbi.nlm.nih.gov/pubmed/37620860
http://dx.doi.org/10.1186/s12964-023-01242-w

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