Senescence in yeast is associated with amplified linear fragments of chromosome XII rather than ribosomal DNA circle accumulation

The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast mother cells has been long cited as the primary driver of replicative ageing. ERCs arise through ribosomal DNA (rDNA) recombination, and a wealth of genetic data connects rDNA instability events giving rise to ERCs wi...

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Detalles Bibliográficos
Autores principales: Zylstra, Andre, Hadj-Moussa, Hanane, Horkai, Dorottya, Whale, Alex J., Piguet, Baptiste, Houseley, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464983/
https://www.ncbi.nlm.nih.gov/pubmed/37643194
http://dx.doi.org/10.1371/journal.pbio.3002250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464983/
https://www.ncbi.nlm.nih.gov/pubmed/37643194
http://dx.doi.org/10.1371/journal.pbio.3002250

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