Elucidation of genome-wide understudied proteins targeted by PROTAC-induced degradation using interpretable machine learning

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Proteolysis-targeting chimeras (PROTACs) are hetero-bifunctional molecules that induce the degradation of target proteins by recruiting an E3 ligase. PROTACs have the potential to inactivate disease-related genes that are considered undruggable by small molecules, making them a promising therapy for...

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Detalles Bibliográficos
Autores principales: Xie, Li, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464998/
https://www.ncbi.nlm.nih.gov/pubmed/37590332
http://dx.doi.org/10.1371/journal.pcbi.1010974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10464998/
https://www.ncbi.nlm.nih.gov/pubmed/37590332
http://dx.doi.org/10.1371/journal.pcbi.1010974

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