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Optogenetic cleavage of the Miro GTPase reveals the direct consequences of real-time loss of function in Drosophila

Miro GTPases control mitochondrial morphology, calcium homeostasis, and regulate mitochondrial distribution by mediating their attachment to the kinesin and dynein motor complex. It is not clear, however, how Miro proteins spatially and temporally integrate their function as acute disruption of prot...

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Detalles Bibliográficos
Autores principales: Mattedi, Francesca, Lloyd-Morris, Ethlyn, Hirth, Frank, Vagnoni, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465005/
https://www.ncbi.nlm.nih.gov/pubmed/37590319
http://dx.doi.org/10.1371/journal.pbio.3002273