Cargando…

Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma

Background: Hepatic fibrosis is a premalignant lesion, and how injured hepatocytes transform into malignancy in a fibrotic microenvironment is poorly understood. Senescence is one of major fates of activated hepatic stellate cells (HSCs). Paucity of literature is available regarding the influence of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yuan, Zhang, Li, Ma, Yue, Xie, Li, Yang, Yong-yu, Jin, Cheng, Chen, Hui, Zhou, Ying, Song, Guang-qi, Ding, Jia, Wu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465212/ https://www.ncbi.nlm.nih.gov/pubmed/37649614 http://dx.doi.org/10.7150/thno.85369

Ejemplares similares

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
por: Min, Kyounghee, et al.
Publicado: (2023)

Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice
por: Teratani, Toshiaki, et al.
Publicado: (2019)

Targeting Endothelial Necroptosis Disrupts Profibrotic Endothelial–Hepatic Stellate Cells Crosstalk to Alleviate Liver Fibrosis in Nonalcoholic Steatohepatitis
por: Yan, Mengli, et al.
Publicado: (2023)

FBP1 loss disrupts liver metabolism and promotes tumourigenesis through a hepatic stellate cell senescence secretome
por: Li, Fuming, et al.
Publicado: (2020)

The mechanism of increased intestinal palmitic acid absorption and its impact on hepatic stellate cell activation in nonalcoholic steatohepatitis
por: Hanayama, Masakazu, et al.
Publicado: (2021)

Serum Glycoprotein Markers in Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
por: Ramachandran, Prasanna, et al.
Publicado: (2022)

Neutrophil–Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis
por: Zhou, Zhou, et al.
Publicado: (2018)

Nonalcoholic steatohepatitis and hepatocellular carcinoma: Brazilian survey
por: Cotrim, Helma P., et al.
Publicado: (2016)

Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma: Brazilian Survey
por: Alves, Venancio Avancini Ferreira, et al.
Publicado: (2016)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice
por: Kim, Kyung Eun, et al.
Publicado: (2023)

Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
por: Yenilmez, Batuhan, et al.
Publicado: (2023)

The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
por: Cha, Ji-Young, et al.
Publicado: (2018)

Immunological distinctions between nonalcoholic steatohepatitis and hepatocellular carcinoma
por: Koo, Seo-Young, et al.
Publicado: (2020)

Nonalcoholic steatohepatitis and hepatocellular carcinoma: Beyond the boundaries of the liver
por: Gupta, Tarana
Publicado: (2022)

Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
por: Vetuschi, Antonella, et al.
Publicado: (2022)

The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis
por: Liu, Boqiang, et al.
Publicado: (2022)

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy
por: Thomes, Paul G., et al.
Publicado: (2016)

Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma
por: Kutlu, Ozlem, et al.
Publicado: (2018)

Inflammatory Mechanisms Underlying Nonalcoholic Steatohepatitis and the Transition to Hepatocellular Carcinoma
por: Peiseler, Moritz, et al.
Publicado: (2021)

Emerging Roles of T Cells in the Pathogenesis of Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
por: Hirsova, Petra, et al.
Publicado: (2021)

Necroptosis in Nonalcoholic Steatohepatitis
por: Gautheron, Jérémie, et al.
Publicado: (2015)

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
por: Rady, Brian, et al.
Publicado: (2021)

Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells
por: Lee, Hae Lim, et al.
Publicado: (2022)

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
por: Hall, Katherine C., et al.
Publicado: (2019)

Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis
por: Yuan, Xiwei, et al.
Publicado: (2023)

The relationship between hepatic resistin overexpression and inflammation in patients with nonalcoholic steatohepatitis
por: Shen, Chuan, et al.
Publicado: (2014)

Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma
por: Cernea, Simona, et al.
Publicado: (2023)

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis
por: McKee, Chad, et al.
Publicado: (2015)

Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma
por: Liu, Boyuan, et al.
Publicado: (2022)

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
por: Luther, Jay, et al.
Publicado: (2015)

Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis
por: Chen, Yongyan, et al.
Publicado: (2020)

Hepatic gene expression and functional changes associated with nonalcoholic steatohepatitis
por: Matsumoto, Kana, et al.
Publicado: (2022)

Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis
por: Sharpe, Martin C., et al.
Publicado: (2023)

Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment
por: Ceccato, Tova L., et al.
Publicado: (2020)

Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma: A Western Experience
por: Shrager, Brian, et al.
Publicado: (2012)

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma
por: Wu, Jian
Publicado: (2016)

Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma
por: Sircana, Antonio, et al.
Publicado: (2019)

The associations of total testosterone with probable nonalcoholic steatohepatitis and nonalcoholic fatty liver disease fibrotic progression in men with type 2 diabetes: a cross-sectional study
por: Zhang, Ziteng, et al.
Publicado: (2022)

Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Analysis of isolated hepatic stellate cells
por: KIM, MINA, et al.
Publicado: (2012)

Apoptosis and diagnosis of nonalcoholic steatohepatitis
por: Kim, Chang Wook, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vrv91ps3gceu9i92ti9a2vtat6