Penfluroidol Attenuates the Imbalance of the Inflammatory Response by Repressing the Activation of the NLRP3 Inflammasome and Reduces Oxidative Stress via the Nrf2/HO-1 Signaling Pathway in LPS-Induced Macrophages

OBJECTIVES: Excessive inflammatory responses and reactive oxygen species (ROS) formation play pivotal roles in the pathogenesis of sepsis. Penfluroidol (PF), an oral long-acting antipsychotic drug, has been suggested to possess diverse biological properties, including antischizophrenia, antitumour e...

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Detalles Bibliográficos
Autores principales: Li, Qiulin, Wu, Lidong, Cheng, Bin, Tao, Shaoyu, Wang, Wei, Luo, Zhiqiang, Fan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465250/
https://www.ncbi.nlm.nih.gov/pubmed/37650025
http://dx.doi.org/10.1155/2023/9940858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465250/
https://www.ncbi.nlm.nih.gov/pubmed/37650025
http://dx.doi.org/10.1155/2023/9940858

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