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Barcoded multiple displacement amplification for high coverage sequencing in spatial genomics

Determining mutational landscapes in a spatial context is essential for understanding genetically heterogeneous cell microniches. Current approaches, such as Multiple Displacement Amplification (MDA), offer high genome coverage but limited multiplexing, which hinders large-scale spatial genomic stud...

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Detalles Bibliográficos
Autores principales: Kim, Jinhyun, Kim, Sungsik, Yeom, Huiran, Song, Seo Woo, Shin, Kyoungseob, Bae, Sangwook, Ryu, Han Suk, Kim, Ji Young, Choi, Ahyoun, Lee, Sumin, Ryu, Taehoon, Choi, Yeongjae, Kim, Hamin, Kim, Okju, Jung, Yushin, Kim, Namphil, Han, Wonshik, Lee, Han-Byoel, Lee, Amos C., Kwon, Sunghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465490/
https://www.ncbi.nlm.nih.gov/pubmed/37644058
http://dx.doi.org/10.1038/s41467-023-41019-w