Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia

Persistence of leukemic stem cells (LSCs) is one of the determining factors to acute myeloid leukemia (AML) treatment failure and responsible for the poor prognosis of the disease. Hence, novel therapeutic strategies that target LSCs are crucial for treatment success. We investigated if targeting Bc...

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Detalles Bibliográficos
Autores principales: Xie, Chendi, Zhou, Hui, Qin, Dongmei, Zheng, Huijian, Tang, Yuanfang, Li, Wenjuan, Zhou, Jie, Liu, Long, Yu, Xinxin, Duan, Hongpeng, Zhou, Yong, Li, Zhifeng, Fang, Zhihong, Luo, Yiming, Carter, Bing Z., Xu, Bing, Zha, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465498/
https://www.ncbi.nlm.nih.gov/pubmed/37644011
http://dx.doi.org/10.1038/s41419-023-06075-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465498/
https://www.ncbi.nlm.nih.gov/pubmed/37644011
http://dx.doi.org/10.1038/s41419-023-06075-6

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