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Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia
Persistence of leukemic stem cells (LSCs) is one of the determining factors to acute myeloid leukemia (AML) treatment failure and responsible for the poor prognosis of the disease. Hence, novel therapeutic strategies that target LSCs are crucial for treatment success. We investigated if targeting Bc...
Autores principales: | Xie, Chendi, Zhou, Hui, Qin, Dongmei, Zheng, Huijian, Tang, Yuanfang, Li, Wenjuan, Zhou, Jie, Liu, Long, Yu, Xinxin, Duan, Hongpeng, Zhou, Yong, Li, Zhifeng, Fang, Zhihong, Luo, Yiming, Carter, Bing Z., Xu, Bing, Zha, Jie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465498/ https://www.ncbi.nlm.nih.gov/pubmed/37644011 http://dx.doi.org/10.1038/s41419-023-06075-6 |
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