P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate

WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by sas16 (P450(Sas)) has been shown to be essential for the formation o...

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Detalles Bibliográficos
Autores principales: Zhang, Songya, Zhang, Lin, Greule, Anja, Tailhades, Julien, Marschall, Edward, Prasongpholchai, Panward, Leng, Daniel J., Zhang, Jingfan, Zhu, Jing, Kaczmarski, Joe A., Schittenhelm, Ralf B., Einsle, Oliver, Jackson, Colin J., Alberti, Fabrizio, Bechthold, Andreas, Zhang, Youming, Tosin, Manuela, Si, Tong, Cryle, Max J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465960/
https://www.ncbi.nlm.nih.gov/pubmed/37655329
http://dx.doi.org/10.1016/j.apsb.2023.03.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465960/
https://www.ncbi.nlm.nih.gov/pubmed/37655329
http://dx.doi.org/10.1016/j.apsb.2023.03.021

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