Cargando…

Versatile flexible micelles integrating mucosal penetration and intestinal targeting for effectively oral delivery of paclitaxel

The extremely low bioavailability of oral paclitaxel (PTX) mainly due to the complicated gastrointestinal environment, the obstruction of intestinal mucus layer and epithelium barrier. Thus, it is of great significance to construct a coordinative delivery system which can overcome multiple intestina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Chao, Liu, Wei, Liu, Yanhong, Duan, Hongxia, Chen, Liqing, Zhang, Xintong, Jin, Mingji, Cui, Minhu, Quan, Xiuquan, Pan, Libin, Hu, Jiachun, Gao, Zhonggao, Wang, Yan, Huang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466001/ https://www.ncbi.nlm.nih.gov/pubmed/37655335 http://dx.doi.org/10.1016/j.apsb.2023.05.029

Ejemplares similares

Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice
por: Jin, Mingji, et al.
Publicado: (2021)

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model
por: Wu, Hao, et al.
Publicado: (2022)

Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes
por: Wang, Mengjiao, et al.
Publicado: (2019)

Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes
por: Jin, Mingji, et al.
Publicado: (2018)

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs
por: Liu, Wei, et al.
Publicado: (2022)

Correction: Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs
por: Liu, Wei, et al.
Publicado: (2022)

Development of Novel Paclitaxel-Loaded ZIF-8 Metal-Organic Framework Nanoparticles Modified with Peptide Dimers and an Evaluation of Its Inhibitory Effect against Prostate Cancer Cells
por: Zhao, Heming, et al.
Publicado: (2023)

Development and Evaluation of a PSMA-Targeted Nanosystem Co-Packaging Docetaxel and Androgen Receptor siRNA for Castration-Resistant Prostate Cancer Treatment
por: Zhang, Yingying, et al.
Publicado: (2022)

Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma
por: Li, Yunfei, et al.
Publicado: (2014)

The influence of the gut microbiota on the bioavailability of oral drugs
por: Zhang, Xintong, et al.
Publicado: (2021)

Co-Delivery of Repurposing Itraconazole and VEGF siRNA by Composite Nanoparticulate System for Collaborative Anti-Angiogenesis and Anti-Tumor Efficacy against Breast Cancer
por: Jin, Mingji, et al.
Publicado: (2022)

Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model
por: Li, Yunfei, et al.
Publicado: (2014)

Research advances in peptide‒drug conjugates
por: Gong, Liming, et al.
Publicado: (2023)

Recent advances in drug delivery systems for targeting cancer stem cells
por: Duan, Hongxia, et al.
Publicado: (2021)

Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways
por: Wang, Shuangqing, et al.
Publicado: (2023)

Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67
por: Cui, Minhu, et al.
Publicado: (2020)

Research Advances in Nucleic Acid Delivery System for Rheumatoid Arthritis Therapy
por: Zhang, Xintong, et al.
Publicado: (2023)

Versatile pH-response Micelles with High Cell-Penetrating Helical Diblock Copolymers for Photoacoustic Imaging Guided Synergistic Chemo-Photothermal Therapy
por: Shi, Shengyu, et al.
Publicado: (2016)

Development of Mitomycin C-Loaded Nanoparticles Prepared Using the Micellar Assembly Driven by the Combined Effect of Hydrogen Bonding and π–π Stacking and Its Therapeutic Application in Bladder Cancer
por: Qi, Lingling, et al.
Publicado: (2021)

Topical Application of JAK1/JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice
por: Jin, Wenyu, et al.
Publicado: (2018)

siRNA-loaded poly(histidine-arginine)(6)-modified chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis
por: Sun, Ping, et al.
Publicado: (2017)

Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid
por: Han, Lingfei, et al.
Publicado: (2019)

A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery
por: Ma, Boxuan, et al.
Publicado: (2018)

Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
por: Tian, Wei, et al.
Publicado: (2015)

β-Cyclodextrin-Based Inclusion Complexation Bridged Biodegradable Self-Assembly Macromolecular Micelle for the Delivery of Paclitaxel
por: Chen, Yanzuo, et al.
Publicado: (2016)

Dual functionalized hyaluronic acid micelles loading paclitaxel for the therapy of breast cancer
por: Liu, Zhanbiao, et al.
Publicado: (2023)

Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
por: Han, Ying, et al.
Publicado: (2019)

l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel
por: Yang, Tan, et al.
Publicado: (2020)

Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel
por: Zhao, Meirong, et al.
Publicado: (2022)

Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration
por: Chen, Nianhang, et al.
Publicado: (2015)

c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma
por: Huang, YuKun, et al.
Publicado: (2016)

Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis
por: Li, Huilan, et al.
Publicado: (2023)

Systemic siRNA Delivery with a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma
por: Fan, Bo, et al.
Publicado: (2017)

Novel amphiphilic folic acid-cholesterol-chitosan micelles for paclitaxel delivery
por: Cheng, Li-Chun, et al.
Publicado: (2016)

Correction: Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy
por: Tang, Dongyang, et al.
Publicado: (2020)

Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment
por: Kang, Lin, et al.
Publicado: (2015)

Correction: Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis
por: Li, Huilan, et al.
Publicado: (2023)

Dehydroascorbic Acids-modified Polymer Micelles Target Cancer Cells to Enhance Anti-tumor Efficacy of Paclitaxel
por: Pei, Xiaoyu, et al.
Publicado: (2017)

Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles
por: Yang, Fu-Heng, et al.
Publicado: (2015)

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel
por: Zhang, Xiaomin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_qoa82f3s26afi36b26gf0iodhv