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Potentiation of PIEZO2 mechanically-activated currents in sensory neurons mediates vincristine-induced mechanical hypersensitivity

Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia. However, mechanisms underlying vincristine-induced mechanic...

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Detalles Bibliográficos
Autores principales: Duan, Mingli, Jia, Yurui, Huo, Lifang, Gao, Yiting, Wang, Jia, Zhang, Wei, Jia, Zhanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466006/
https://www.ncbi.nlm.nih.gov/pubmed/37655331
http://dx.doi.org/10.1016/j.apsb.2023.05.010