Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes

BACKGROUND: The Bruton tyrosine kinase (BTK) inhibitor Ibrutinib is associated with a higher incidence of cardiotoxic side effects including heart failure (HF). OBJECTIVES: Ibrutinib is capable of inhibiting PI3K/Akt signaling in neonatal rat ventricular cardiomyocytes when stimulated with insulin-l...

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Detalles Bibliográficos
Autores principales: Tarnowski, Daniel, Feder, Anna-Lena, Trum, Maximilian, Kreitmeier, Klaus-Georg, Stengel, Laura, Maier, Lars S., Sag, Can Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466040/
https://www.ncbi.nlm.nih.gov/pubmed/37655217
http://dx.doi.org/10.3389/fcvm.2023.1190099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466040/
https://www.ncbi.nlm.nih.gov/pubmed/37655217
http://dx.doi.org/10.3389/fcvm.2023.1190099

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