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The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases

Physical activity (PA), which includes exercise, can reduce the risk of developing various non-communicable diseases, including neurodegenerative diseases (NDs), and mitigate their adverse effects. However, the mechanisms underlying this ability are not yet fully understood. Among several possible m...

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Autores principales: Fischetti, Francesco, Poli, Luca, De Tommaso, Marina, Paolicelli, Damiano, Greco, Gianpiero, Cataldi, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466047/
https://www.ncbi.nlm.nih.gov/pubmed/37654673
http://dx.doi.org/10.3389/fphys.2023.1241010
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author Fischetti, Francesco
Poli, Luca
De Tommaso, Marina
Paolicelli, Damiano
Greco, Gianpiero
Cataldi, Stefania
author_facet Fischetti, Francesco
Poli, Luca
De Tommaso, Marina
Paolicelli, Damiano
Greco, Gianpiero
Cataldi, Stefania
author_sort Fischetti, Francesco
collection PubMed
description Physical activity (PA), which includes exercise, can reduce the risk of developing various non-communicable diseases, including neurodegenerative diseases (NDs), and mitigate their adverse effects. However, the mechanisms underlying this ability are not yet fully understood. Among several possible mechanisms proposed, such as the stimulation of brain-derived neurotrophic factor (BDNF), endothelial nitric oxide synthase (eNOS), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), the possible involvement of particular vesicular structures enclosed in lipid membranes known as extracellular vesicles (EVs) has recently been investigated. These EVs would appear to exert a paracrine and systemic action through their ability to carry various molecules, particularly so-called microRNAs (miRNAs), performing a function as mediators of intercellular communication. Interestingly, EVs and miRNAs are differentially expressed following PA, but evidence on how different exercise parameters may differentially affect EVs and the miRNAs they carry is still scarce. In this review we summarized the current human findings on the effects of PA and different exercise parameters exerted on EVs and their cargo, focusing on miRNAs molecules, and discussing how this may represent one of the biological mechanisms through which exercise contributes to preventing and slowing NDs.
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spelling pubmed-104660472023-08-31 The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases Fischetti, Francesco Poli, Luca De Tommaso, Marina Paolicelli, Damiano Greco, Gianpiero Cataldi, Stefania Front Physiol Physiology Physical activity (PA), which includes exercise, can reduce the risk of developing various non-communicable diseases, including neurodegenerative diseases (NDs), and mitigate their adverse effects. However, the mechanisms underlying this ability are not yet fully understood. Among several possible mechanisms proposed, such as the stimulation of brain-derived neurotrophic factor (BDNF), endothelial nitric oxide synthase (eNOS), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), the possible involvement of particular vesicular structures enclosed in lipid membranes known as extracellular vesicles (EVs) has recently been investigated. These EVs would appear to exert a paracrine and systemic action through their ability to carry various molecules, particularly so-called microRNAs (miRNAs), performing a function as mediators of intercellular communication. Interestingly, EVs and miRNAs are differentially expressed following PA, but evidence on how different exercise parameters may differentially affect EVs and the miRNAs they carry is still scarce. In this review we summarized the current human findings on the effects of PA and different exercise parameters exerted on EVs and their cargo, focusing on miRNAs molecules, and discussing how this may represent one of the biological mechanisms through which exercise contributes to preventing and slowing NDs. Frontiers Media S.A. 2023-08-15 /pmc/articles/PMC10466047/ /pubmed/37654673 http://dx.doi.org/10.3389/fphys.2023.1241010 Text en Copyright © 2023 Fischetti, Poli, De Tommaso, Paolicelli, Greco and Cataldi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Fischetti, Francesco
Poli, Luca
De Tommaso, Marina
Paolicelli, Damiano
Greco, Gianpiero
Cataldi, Stefania
The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title_full The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title_fullStr The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title_full_unstemmed The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title_short The role of exercise parameters on small extracellular vesicles and microRNAs cargo in preventing neurodegenerative diseases
title_sort role of exercise parameters on small extracellular vesicles and micrornas cargo in preventing neurodegenerative diseases
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466047/
https://www.ncbi.nlm.nih.gov/pubmed/37654673
http://dx.doi.org/10.3389/fphys.2023.1241010
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