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Chiral gem-difluoroalkyl reagents: gem-difluoroalkyl propargylic borons and gem-difluoroalkyl α-allenols

Chiral fluorinated reagents provide new opportunities for the discovery of drugs and functional materials because the introduction of a fluorinated group significantly alters a molecule's physicochemical properties. Chiral gem-difluoroalkyl fragments (R–CF(2)–C*) are key motifs in many drugs. H...

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Detalles Bibliográficos
Autores principales: Zou, Hui-Na, Huang, Meng-Lin, Huang, Ming-Yao, Su, Yu-Xuan, Zhang, Jing-Wei, Zhang, Xin-Yu, Zhu, Shou-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466307/
https://www.ncbi.nlm.nih.gov/pubmed/37655040
http://dx.doi.org/10.1039/d3sc03266c