Highly enantioselective Rh-catalyzed asymmetric reductive dearomatization of multi-nitrogen polycyclic pyrazolo[1,5-a]pyrimidines

A highly enantioselective rhodium-catalyzed reductive dearomatization of 7-substituted pyrazolo[1,5-a]pyrimidines has been realized for the first time by two strategies to afford chiral 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines with excellent enantioselectivities of up to 98% ee. This method also...

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Detalles Bibliográficos
Autores principales: Xie, Chaochao, Xiao, Guiying, Guo, Qianling, Wu, Xiaoxue, Zi, Guofu, Ding, Wanjian, Hou, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466315/
https://www.ncbi.nlm.nih.gov/pubmed/37655036
http://dx.doi.org/10.1039/d3sc02086j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466315/
https://www.ncbi.nlm.nih.gov/pubmed/37655036
http://dx.doi.org/10.1039/d3sc02086j

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