De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework

[Image: see text] Likely effective pharmacological interventions for the treatment of opioid addiction include attempts to attenuate brain reward deficits during periods of abstinence. Pharmacological blockade of the κ-opioid receptor (KOR) has been shown to abolish brain reward deficits in rodents...

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Detalles Bibliográficos
Autores principales: Salas-Estrada, Leslie, Provasi, Davide, Qiu, Xing, Kaniskan, Husnu Ümit, Huang, Xi-Ping, DiBerto, Jeffrey F., Lamim Ribeiro, João Marcelo, Jin, Jian, Roth, Bryan L., Filizola, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466374/
https://www.ncbi.nlm.nih.gov/pubmed/37555591
http://dx.doi.org/10.1021/acs.jcim.3c00651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466374/
https://www.ncbi.nlm.nih.gov/pubmed/37555591
http://dx.doi.org/10.1021/acs.jcim.3c00651

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