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De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework
[Image: see text] Likely effective pharmacological interventions for the treatment of opioid addiction include attempts to attenuate brain reward deficits during periods of abstinence. Pharmacological blockade of the κ-opioid receptor (KOR) has been shown to abolish brain reward deficits in rodents...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466374/ https://www.ncbi.nlm.nih.gov/pubmed/37555591 http://dx.doi.org/10.1021/acs.jcim.3c00651 |