Inhibition Mechanism of Anti-TB Drug SQ109: Allosteric Inhibition of TMM Translocation of Mycobacterium Tuberculosis MmpL3 Transporter

[Image: see text] The mycolic acid transporter MmpL3 is driven by proton motive forces (PMF) and functions via an antiport mechanism. Although the crystal structures of the Mycobacterium smegmatis MmpL3 transporter alone and in complex with a trehalose monomycolate (TMM) substrate and an antitubercu...

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Detalles Bibliográficos
Autores principales: Carbone, Justin, Paradis, Nicholas J., Bennet, Lucas, Alesiani, Mark C., Hausman, Katherine R., Wu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466384/
https://www.ncbi.nlm.nih.gov/pubmed/37589273
http://dx.doi.org/10.1021/acs.jcim.3c00616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466384/
https://www.ncbi.nlm.nih.gov/pubmed/37589273
http://dx.doi.org/10.1021/acs.jcim.3c00616

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