A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis

BACKGROUND: Our study aims to investigate an intrinsic link underlying sex hormone-binding globulin (SHBG) and rheumatoid arthritis (RA), which remains inconclusive in observational settings. METHODS: Summary statistics were collected from the largest GWAS(s) on SHBG adjusted for BMI (SHBG(adj)BMI;...

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Detalles Bibliográficos
Autores principales: Jiang, Yuan, Liu, Qianwen, Alfredsson, Lars, Klareskog, Lars, Kockum, Ingrid, Jiang, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466838/
https://www.ncbi.nlm.nih.gov/pubmed/37644603
http://dx.doi.org/10.1186/s40246-023-00528-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466838/
https://www.ncbi.nlm.nih.gov/pubmed/37644603
http://dx.doi.org/10.1186/s40246-023-00528-x

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