Cargando…

A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis

BACKGROUND: Our study aims to investigate an intrinsic link underlying sex hormone-binding globulin (SHBG) and rheumatoid arthritis (RA), which remains inconclusive in observational settings. METHODS: Summary statistics were collected from the largest GWAS(s) on SHBG adjusted for BMI (SHBG(adj)BMI;...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Yuan, Liu, Qianwen, Alfredsson, Lars, Klareskog, Lars, Kockum, Ingrid, Jiang, Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10466838/ https://www.ncbi.nlm.nih.gov/pubmed/37644603 http://dx.doi.org/10.1186/s40246-023-00528-x

Ejemplares similares

Obesity‐Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data
por: Tang, Bowen, et al.
Publicado: (2020)

Prevention vs treatment of rheumatoid arthritis
por: Klareskog, Lars, et al.
Publicado: (2023)

Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking
por: Tang, Bowen, et al.
Publicado: (2023)

Relationship between shift work and the onset of rheumatoid arthritis
por: Hedström, Anna Karin, et al.
Publicado: (2017)

Response to Comment “Sex-specific exposures and sex-combined outcomes in two-sample Mendelian randomization may mislead the causal inference” on “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis—a Mendelian randomization study”
por: Zhu, Jingjing, et al.
Publicado: (2022)

Exposure to passive smoking and rheumatoid arthritis risk: results from the Swedish EIRA study
por: Hedström, Anna Karin, et al.
Publicado: (2018)

Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study
por: Orellana, Cecilia, et al.
Publicado: (2015)

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study
por: Zhu, Jingjing, et al.
Publicado: (2021)

Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study
por: Hedström, Anna Karin, et al.
Publicado: (2018)

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
por: Padyukov, Leonid, et al.
Publicado: (2010)

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate
por: Altawil, Reem, et al.
Publicado: (2016)

Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study
por: Sverdrup, Berit M, et al.
Publicado: (2012)

Working in cold environment and risk of developing rheumatoid arthritis: results from the Swedish EIRA case–control study
por: Zeng, Pingling, et al.
Publicado: (2017)

Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case–control study
por: Zeng, Pingling, et al.
Publicado: (2017)

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis
por: Meng, Weida, et al.
Publicado: (2017)

Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study
por: Orellana, Cecilia, et al.
Publicado: (2017)

Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study
por: Westerlind, Helga, et al.
Publicado: (2021)

Unmet Needs in Rheumatoid Arthritis: A Subgroup of Patients With High Levels of Pain, Fatigue, and Psychosocial Distress 3 Years After Diagnosis
por: Lindqvist, Joakim, et al.
Publicado: (2022)

Allergic conditions and risk of rheumatoid arthritis: a Swedish case–control study
por: Kronzer, Vanessa L, et al.
Publicado: (2022)

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis
por: Liu, Qianwen, et al.
Publicado: (2022)

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register
por: Jiang, Xia, et al.
Publicado: (2015)

Complex Relationships of Smoking, HLA–DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population‐Based Case–Control Study
por: Hedström, Anna Karin, et al.
Publicado: (2019)

A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome
por: Liu, Qianwen, et al.
Publicado: (2022)

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
por: Saevarsdottir, Saedis, et al.
Publicado: (2011)

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
por: Bellomo, Tiffany R., et al.
Publicado: (2022)

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study
por: Lyne, Lauren, et al.
Publicado: (2022)

Analysis of Neuropeptide S Receptor Gene (NPSR1) Polymorphism in Rheumatoid Arthritis
por: D'Amato, Mauro, et al.
Publicado: (2010)

Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis
por: Eriksson, Kaja, et al.
Publicado: (2018)

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study
por: Sverdrup, Berit, et al.
Publicado: (2005)

Modifiable environmental exposure and risk of rheumatoid arthritis—current evidence from genetic studies
por: Jiang, Xia, et al.
Publicado: (2020)

Genes and environment in arthritis: can RA be prevented?
por: Klareskog, Lars, et al.
Publicado: (2002)

Effects of GSTM1 in Rheumatoid Arthritis; Results from the Swedish EIRA study
por: Lundström, Emeli, et al.
Publicado: (2011)

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis
por: Too, Chun Lai, et al.
Publicado: (2012)

Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study
por: Ilar, Anna, et al.
Publicado: (2019)

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material
por: Pikwer, Mitra, et al.
Publicado: (2015)

Anti-citrullinated protein antibody specificities and pulmonary fibrosis in relation to genetic loci in early rheumatoid arthritis
por: Brink, Mikael, et al.
Publicado: (2022)

Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
por: Too, Chun Lai, et al.
Publicado: (2016)

Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate‐Treated Early Rheumatoid Arthritis Patients
por: Lourdudoss, Cecilia, et al.
Publicado: (2018)

Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up
por: Manivel, Vivek Anand, et al.
Publicado: (2017)

Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?
por: Malmström, Vivianne, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_lnrro11hgpff5vl32q245oc6ls