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Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons
Volatile anesthetics reduce excitatory synaptic transmission by both presynaptic and postsynaptic mechanisms which include inhibition of depolarization-evoked increases in presynaptic Ca(2+) concentration and blockade of postsynaptic excitatory glutamate receptors. The presynaptic sites of action le...
Autores principales: | Osman, Vanessa, Speigel, Iris, Patel, Kishan, Hemmings, Hugh C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467020/ https://www.ncbi.nlm.nih.gov/pubmed/37591734 http://dx.doi.org/10.1523/ENEURO.0114-23.2023 |
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