Probing the structure of human tRNA(3)(Lys) in the presence of ligands using docking, MD simulations and MSM analysis

The tRNA(3)(Lys), which acts as a primer for human immunodeficiency virus type 1 (HIV-1) reverse transcription, undergoes structural changes required for the formation of a primer–template complex. Small molecules have been targeted against tRNA(3)(Lys) to inhibit the primer–template complex formati...

Descripción completa

Detalles Bibliográficos
Autores principales: Uppuladinne, Mallikarjunachari V. N., Achalere, Archana, Sonavane, Uddhavesh, Joshi, Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467029/
https://www.ncbi.nlm.nih.gov/pubmed/37655355
http://dx.doi.org/10.1039/d3ra03694d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467029/
https://www.ncbi.nlm.nih.gov/pubmed/37655355
http://dx.doi.org/10.1039/d3ra03694d

Ejemplares similares