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Probing the structure of human tRNA(3)(Lys) in the presence of ligands using docking, MD simulations and MSM analysis

The tRNA(3)(Lys), which acts as a primer for human immunodeficiency virus type 1 (HIV-1) reverse transcription, undergoes structural changes required for the formation of a primer–template complex. Small molecules have been targeted against tRNA(3)(Lys) to inhibit the primer–template complex formati...

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Detalles Bibliográficos
Autores principales:	Uppuladinne, Mallikarjunachari V. N., Achalere, Archana, Sonavane, Uddhavesh, Joshi, Rajendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467029/ https://www.ncbi.nlm.nih.gov/pubmed/37655355 http://dx.doi.org/10.1039/d3ra03694d

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