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Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Alpha‐synuclein (αsyn) aggregates are pathological features of several neurodegenerative conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple system atrophy (MSA). Accumulating evidence suggests that mitochondrial dysfunction and impairments of the autophagic‐lysosoma...

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Detalles Bibliográficos
Autores principales: Hou, Xu, Chen, Taylor Hsuan‐Yu, Koga, Shunsuke, Bredenberg, Jenny M., Faroqi, Ayman H., Delenclos, Marion, Bu, Guojun, Wszolek, Zbigniew K., Carr, Jonathan A., Ross, Owen A., McLean, Pamela J., Murray, Melissa E., Dickson, Dennis W., Fiesel, Fabienne C., Springer, Wolfdieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467041/
https://www.ncbi.nlm.nih.gov/pubmed/37259617
http://dx.doi.org/10.1111/bpa.13175