Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity

Mycolactone is an exotoxin produced by Mycobacterium ulcerans that causes the neglected tropical skin disease Buruli ulcer. This toxin inhibits the Sec61 translocon in the endoplasmic reticulum (ER), preventing the host cell from producing several secretory and transmembrane proteins, resulting in c...

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Detalles Bibliográficos
Autores principales: Nguyen, John D. M., da Hora, Gabriel C. A., Swanson, Jessica M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467071/
https://www.ncbi.nlm.nih.gov/pubmed/37624243
http://dx.doi.org/10.3390/toxins15080486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467071/
https://www.ncbi.nlm.nih.gov/pubmed/37624243
http://dx.doi.org/10.3390/toxins15080486

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