Cargando…

Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2

Seven new peptides denominated CboK1 to CboK7 were isolated from the venom of the Mexican scorpion Centruroides bonito and their primary structures were determined. The molecular weights ranged between 3760.4 Da and 4357.9 Da, containing 32 to 39 amino acid residues with three putative disulfide bri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shakeel, Kashmala, Olamendi-Portugal, Timoteo, Naseem, Muhammad Umair, Becerril, Baltazar, Zamudio, Fernando Z., Delgado-Prudencio, Gustavo, Possani, Lourival Domingos, Panyi, Gyorgy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467108/ https://www.ncbi.nlm.nih.gov/pubmed/37624263 http://dx.doi.org/10.3390/toxins15080506

Ejemplares similares

Full Neutralization of Centruroides sculpturatus Scorpion Venom by Combining Two Human Antibody Fragments
por: Riaño-Umbarila, Lidia, et al.
Publicado: (2021)

Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae)
por: Valdez-Velázquez, Laura L., et al.
Publicado: (2018)

Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment
por: Valencia-Martínez, Hugo, et al.
Publicado: (2022)

Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1
por: Naseem, Muhammad Umair, et al.
Publicado: (2023)

Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel
por: Beltrán-Vidal, José, et al.
Publicado: (2021)

Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom()
por: Salazar, Marcos H., et al.
Publicado: (2021)

The Dual α-Amidation System in Scorpion Venom Glands
por: Delgado-Prudencio, Gustavo, et al.
Publicado: (2019)

Mass Fingerprinting of the Venom and Transcriptome of Venom Gland of Scorpion Centruroides tecomanus
por: Valdez-Velázquez, Laura L., et al.
Publicado: (2013)

Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms
por: Riaño-Umbarila, Lidia, et al.
Publicado: (2019)

Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species
por: Rendón-Anaya, Martha, et al.
Publicado: (2012)

Inhibition of the Collapse of the Shaker K(+) Conductance by Specific Scorpion Toxins
por: Gómez-Lagunas, Froylan, et al.
Publicado: (2004)

Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879)
por: Cid-Uribe, Jimena I., et al.
Publicado: (2019)

A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5
por: Alvarado, Diana, et al.
Publicado: (2021)

Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion Centruroides possanii (Buthidae) through Omic Technologies
por: García-Villalvazo, Patricia Elizabeth, et al.
Publicado: (2023)

Cm28, a scorpion toxin having a unique primary structure, inhibits K(V)1.2 and K(V)1.3 with high affinity
por: Naseem, Muhammad Umair, et al.
Publicado: (2022)

The material culture of Pueblo Bonito ; With appendix canid remains from Pueblo Bonito and Pueblo del Arrollo
por: Judd, Neil M.
Publicado: (1954)

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
por: Huang, Jie, et al.
Publicado: (2017)

Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6
por: Borrego, Jesús, et al.
Publicado: (2022)

Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki
por: Zou, Yan, et al.
Publicado: (2017)

Methamphetamine Ingestion Misdiagnosed as Centruroides sculpturatus Envenomation
por: Strommen, Joshua, et al.
Publicado: (2015)

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases
por: Ye, Fang, et al.
Publicado: (2016)

Mineral and bone disorder after kidney transplantation (KTx)
por: Neves, Carolina Lara, et al.
Publicado: (2021)

Differential toxicity and venom gland gene expression in Centruroides vittatus
por: McElroy, Thomas, et al.
Publicado: (2017)

The complete mitochondrial genome of the scorpion Centruroides vittatus (Arachnida: Scorpiones)
por: Yamashita, Tsunemi, et al.
Publicado: (2017)

Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus
por: Quintero-Hernández, Verónica, et al.
Publicado: (2015)

Obesity After Kidney Transplantation—Results of a KTx360°Substudy
por: Nöhre, Mariel, et al.
Publicado: (2020)

Effective prevention of sorafenib-induced hand–foot syndrome by dried-bonito broth
por: Kamimura, Kenya, et al.
Publicado: (2018)

Intraspecific Variation of Centruroides Edwardsii Venom from Two Regions of Colombia
por: Estrada-Gómez, Sebastián, et al.
Publicado: (2014)

The unfulfilled promises of scorpion insectotoxins
por: Ortiz, Ernesto, et al.
Publicado: (2015)

The complete mitochondrial genome of Linnemannia amoeboidea (W. Gams) Vandepol & Bonito (Mortierellales: Mortierellaceae)
por: Yang, Yang, et al.
Publicado: (2022)

Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca(2+)-Release Channels/Ryanodine Receptors
por: Gurrola, Georgina B., et al.
Publicado: (2010)

The ultrastructure of book lung development in the bark scorpion Centruroides gracilis (Scorpiones: Buthidae)
por: Farley, Roger D
Publicado: (2011)

Genome Analyses of a New Mycoplasma Species from the Scorpion Centruroides vittatus
por: Yamashita, Tsunemi, et al.
Publicado: (2019)

The Enzymatic Core of Scorpion Venoms
por: Delgado-Prudencio, Gustavo, et al.
Publicado: (2022)

The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane
por: Voros, Orsolya, et al.
Publicado: (2018)

The Ca(2+) Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal
por: Veytia-Bucheli, José Ignacio, et al.
Publicado: (2022)

Reproductive tradeoff limits the predatory efficiency of female Arizona Bark Scorpions (Centruroides sculpturatus)
por: Webber, Michael M, et al.
Publicado: (2013)

A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus
por: Yamashita, Tsunemi, et al.
Publicado: (2023)

The Atlantic Bonito (Sarda sarda, Bloch 1793) Transcriptome and Detection of Differential Expression during Larvae Development
por: Sarropoulou, Elena, et al.
Publicado: (2014)

The deterioration of the Pueblo Bonito Great House in the Chaco Culture National Historical Park, New Mexico, USA
por: Short, Henry L.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sq790odqbm8g82sdl4v9ibosvf