Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S

Fluorine is a key element in medicinal chemistry, as it can significantly enhance the pharmacological properties of drugs. In this study, we aimed to biosynthetically produce fluorinated analogues of the antimicrobial cyclic decapeptide gramicidin S (GS). However, our results show that the A-domain...

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Detalles Bibliográficos
Autores principales: Müll, Maximilian, Pourmasoumi, Farzaneh, Wehrhan, Leon, Nosovska, Olena, Stephan, Philipp, Zeihe, Hannah, Vilotijevic, Ivan, Keller, Bettina G., Kries, Hajo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467612/
https://www.ncbi.nlm.nih.gov/pubmed/37654511
http://dx.doi.org/10.1039/d3cb00061c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467612/
https://www.ncbi.nlm.nih.gov/pubmed/37654511
http://dx.doi.org/10.1039/d3cb00061c

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