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The 2′-hydroxy group of flavin mononucleotide influences the catalytic function and promiscuity of the flavoprotein iodotyrosine dehalogenase

The isoalloxazine ring system of the flavin cofactor is responsible for much of the catalytic power and diversity associated with flavoproteins. While the specificity of these enzymes is greatly influenced by the surrounding protein environment, the ribityl group of the cofactor may also participate...

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Detalles Bibliográficos
Autores principales: Kozyryev, Anton, Boucher, Petrina A., Quiñones-Jurgensen, Carla M., Rokita, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467613/
https://www.ncbi.nlm.nih.gov/pubmed/37654510
http://dx.doi.org/10.1039/d3cb00094j