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PROTAC chemical probes for histone deacetylase enzymes

Over the past three decades, we have witnessed the progression of small molecule chemical probes designed to inhibit the catalytic active site of histone deacetylase (HDAC) enzymes into FDA approved drugs. However, it is only in the past five years we have witnessed the emergence of proteolysis targ...

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Detalles Bibliográficos
Autores principales: Patel, Urvashi, Smalley, Joshua P., Hodgkinson, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10467623/
https://www.ncbi.nlm.nih.gov/pubmed/37654508
http://dx.doi.org/10.1039/d3cb00105a