TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

TERT reactivation occurs frequently in human malignancies, especially advanced cancers. However, in vivo functions of TERT reactivation in cancer progression and the underlying mechanism are not fully understood. In this study, we expressed TERT and/or active BRAF (BRAF V600E) specifically in mouse...

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Detalles Bibliográficos
Autores principales: Yu, Pengcheng, Qu, Ning, Zhu, Rui, Hu, Jiaqian, Han, Peizhen, Wu, Jiahao, Tan, Licheng, Gan, Hualei, He, Cong, Fang, Chuantao, Lei, Yubin, Li, Jian, He, Chenxi, Lan, Fei, Shi, Xiao, Wei, Wenjun, Wang, Yu, Ji, Qinghai, Yu, Fa-Xing, Wang, Yu-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468137/
https://www.ncbi.nlm.nih.gov/pubmed/37647391
http://dx.doi.org/10.1126/sciadv.adg7125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468137/
https://www.ncbi.nlm.nih.gov/pubmed/37647391
http://dx.doi.org/10.1126/sciadv.adg7125

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