Cargando…
CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
The dodecameric protein kinase CaMKII is expressed throughout the body. The alpha isoform is responsible for synaptic plasticity and participates in memory through its phosphorylation of synaptic proteins. Its elaborate subunit organization and propensity for autophosphorylation allow it to preserve...
Autores principales: | Lučić, Iva, Héluin, Léonie, Jiang, Pin-Lian, Castro Scalise, Alejandro G, Wang, Cong, Franz, Andreas, Heyd, Florian, Wahl, Markus C, Liu, Fan, Plested, Andrew JR |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468207/ https://www.ncbi.nlm.nih.gov/pubmed/37566455 http://dx.doi.org/10.7554/eLife.86090 |
Ejemplares similares
-
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity
por: Stratton, Margaret, et al.
Publicado: (2014) -
Correction: Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity
por: Stratton, Margaret, et al.
Publicado: (2014) -
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
por: Bhattacharyya, Moitrayee, et al.
Publicado: (2020) -
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
por: Karandur, Deepti, et al.
Publicado: (2020) -
The CaMKII holoenzyme structure in activation-competent conformations
por: Myers, Janette B., et al.
Publicado: (2017)