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Population-based heteropolymer design to mimic protein mixtures

Biological fluids, the most complex blends, have compositions that constantly vary and cannot be molecularly defined(1). Despite these uncertainties, proteins fluctuate, fold, function and evolve as programmed(2–4). We propose that in addition to the known monomeric sequence requirements, protein se...

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Detalles Bibliográficos
Autores principales: Ruan, Zhiyuan, Li, Shuni, Grigoropoulos, Alexandra, Amiri, Hossein, Hilburg, Shayna L., Chen, Haotian, Jayapurna, Ivan, Jiang, Tao, Gu, Zhaoyi, Alexander-Katz, Alfredo, Bustamante, Carlos, Huang, Haiyan, Xu, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468399/
https://www.ncbi.nlm.nih.gov/pubmed/36890370
http://dx.doi.org/10.1038/s41586-022-05675-0