Cargando…

First-in-human study of a novel cell death tracer [(99m)Tc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

BACKGROUND: Imaging of cell death can provide an early indication of treatment response in cancer. [(99m)Tc]Tc-Duramycin is a small-peptide SPECT tracer that recognizes both apoptotic and necrotic cells by binding to phosphatidylethanolamine present in the cell membrane. Preclinically, this tracer h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Metelerkamp Cappenberg, Taco, De Schepper, Stijn, Vangestel, Christel, De Lombaerde, Stef, wyffels, Leonie, Van den Wyngaert, Tim, Mattis, Jeffrey, Gray, Brian, Pak, Koon, Stroobants, Sigrid, Elvas, Filipe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468453/ https://www.ncbi.nlm.nih.gov/pubmed/37646865 http://dx.doi.org/10.1186/s41181-023-00207-1

Ejemplares similares

Characterization of [(99m)Tc]Duramycin as a SPECT Imaging Agent for Early Assessment of Tumor Apoptosis
por: Elvas, Filipe, et al.
Publicado: (2015)

Monitoring Apoptosis of Breast Cancer Xenograft After Paclitaxel Treatment With (99m)Tc-Labeled Duramycin SPECT/CT
por: Luo, Rui, et al.
Publicado: (2016)

Tc-Glutathione Complex (Tc -GSH) : Labelling, Chemical Characterization and Biodistribution in Rats
por: Baba, K., et al.
Publicado: (1999)

Biodistribution of (99m)Tc Tricarbonyl Glycine Oligomers
por: Jang, Beom-Su, et al.
Publicado: (2012)

Biodistribution of (99m)Tc Labeled Integrin Antagonist
por: Jang, Beom-Su, et al.
Publicado: (2013)

Radiation dosimetry and biodistribution of (99m)Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer
por: Schechter, Naomi R., et al.
Publicado: (2009)

(99m)Tc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study
por: Lambert, Bieke, et al.
Publicado: (2016)

Altered [(99m)Tc]Tc-MDP biodistribution from neutron activation sourced (99)Mo
por: Demeter, Sandor, et al.
Publicado: (2018)

Pharmacokinetics of the phosphatidylserine tracers (99m)Tc-lactadherin and (99m)Tc-annexin V in pigs
por: Poulsen, Runa H, et al.
Publicado: (2013)

Biodistribution and scintigraphic evaluation of 99mTc-Mannan complex
por: Sanguri, Sweta, et al.
Publicado: (2016)

[(99m)Tc]Tc-PSMA-T4—Novel SPECT Tracer for Metastatic PCa: From Bench to Clinic
por: Maurin, Michał, et al.
Publicado: (2022)

Development of Antibody Immuno-PET/SPECT Radiopharmaceuticals for Imaging of Oncological Disorders—An Update
por: Dewulf, Jonatan, et al.
Publicado: (2020)

Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin
por: An, Linna, et al.
Publicado: (2018)

(99m)TcO(4)(-)/(99m)Tc-MIBI dual-tracer scintigraphy for preoperative localization of parathyroid adenomas
por: Huang, Zhongke, et al.
Publicado: (2018)

Optimizing the Profile of [(99m)Tc]Tc–NT(7–13) Tracers in Pancreatic Cancer Models by Means of Protease Inhibitors
por: Kanellopoulos, Panagiotis, et al.
Publicado: (2020)

Synthesis and Biodistribution of (99m)Tc-Labeled PLGA Nanoparticles by Microfluidic Technique
por: Varani, Michela, et al.
Publicado: (2021)

Human biodistribution and radiation dosimetry of the demyelination tracer [(18)F]3F4AP
por: Brugarolas, Pedro, et al.
Publicado: (2022)

Biodistribution and radiation dosimetry of multiple tracers on total-body positron emission tomography/computed tomography
por: Li, Lianghua, et al.
Publicado: (2023)

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [(99m)Tc]Tc-ADAPT6 and [(99m)Tc]Tc-(HE)(3)-G3, for Imaging of HER2-Positive Breast Cancer
por: Bragina, Olga, et al.
Publicado: (2023)

How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research
por: De Bruycker, Sven, et al.
Publicado: (2018)

Preclinical Evaluation of a Novel (18)F-Labeled dTCO-Amide Derivative for Bioorthogonal Pretargeted Positron Emission Tomography Imaging
por: Ruivo, Eduardo, et al.
Publicado: (2020)

[(99m)Tc]Tc-iFAP Radioligand for SPECT/CT Imaging of the Tumor Microenvironment: Kinetics, Radiation Dosimetry, and Imaging in Patients
por: Coria-Domínguez, Luis, et al.
Publicado: (2022)

Biodistribution of Tc-99m Labeled Isoniazid Solid Lipid Nanoparticles in Wistar Rats
por: Ghazizadeh, Fereshteh, et al.
Publicado: (2018)

Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [(18)F]HX4 PET imaging study in colorectal cancer xenografts
por: De Bruycker, Sven, et al.
Publicado: (2019)

Characterization of Structurally Diverse (18)F-Labeled d-TCO Derivatives as a PET Probe for Bioorthogonal Pretargeted Imaging
por: Adhikari, Karuna, et al.
Publicado: (2023)

Comparison of the Absorbed Dose for (99m)Tc-Diethylenetriaminepentaacetic Acid and (99m)Tc-Ethylenedicysteine Radiopharmaceuticals using Medical Internal Radiation Dosimetry
por: Pirdamooie, Shokufeh, et al.
Publicado: (2015)

[(99m)Tc]Tc-DTPA-Bis(cholineethylamine) as an Oncologic Tracer for the Detection of Choline Transporter (ChT) and Choline Kinase (ChK) Expression in Cancer
por: Jaswal, Ambika Parmar, et al.
Publicado: (2022)

Comparison of [(99m)Tc]Tc-tilmanocept with [(99m)Tc]Tc-sulphur colloids and [(99m)Tc]Tc-albumin colloids for sentinel lymph node detection in patients with cutaneous malignancies of the head
por: Ooms, Mark, et al.
Publicado: (2022)

Patient-specific dosimetry of (99m)Tc-HYNIC-Tyr(3)-Octreotide in children
por: Hou, Xinchi, et al.
Publicado: (2017)

Evaluation of Radiation dosimetry of (99m)Tc-HYNIC-PSMA and imaging in prostate cancer
por: Zhang, Jianping, et al.
Publicado: (2020)

(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
por: Hayakawa, Takehito, et al.
Publicado: (2018)

Elucidating Duramycin’s Bacterial Selectivity and Mode of Action on the Bacterial Cell Envelope
por: Hasim, Sahar, et al.
Publicado: (2018)

Sodium pertechnetate (Na99mTcO(4)) biodistribution in mice exposed to cigarette smoke
por: Valenca, Samuel S, et al.
Publicado: (2005)

Diffuse hepatic and splenic Tc-99m MDP tracer uptake in case of multiple myeloma
por: Sood, Ashwani, et al.
Publicado: (2010)

Extraosseous accumulation of bone scan tracer (99m)Tc-methylene diphosphonate in a phlebolith
por: Kulkarni, Mukta, et al.
Publicado: (2012)

Detection of the sentinel lymph node with hybrid tracer (ICG-[(99m)Tc]Tc-albumin nanocolloid) in intermediate- and high-risk endometrial cancer: a feasibility study
por: Sánchez-Izquierdo, Nuria, et al.
Publicado: (2021)

Head to head comparison of [(99m)Tc]Tc(CO)(3)(NTA) and [(99m)Tc]Tc-MAG3 in patients with suspected obstruction
por: Taylor, Andrew T., et al.
Publicado: (2021)

Biokinetics, dosimetry, and radiation risk in infants after (99m)Tc-MAG3 scans
por: Soares Machado, J., et al.
Publicado: (2018)

Factors modulating (99m)Tc‐MAA planar lung dosimetry for (90)Y radioembolization
por: Lopez, Benjamin P., et al.
Publicado: (2022)

Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [(11)C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism
por: Christensen, Nana L., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_85jko19bedgicbtm29ge47bujt