MALAT1/miR‐185‐5p mediated high glucose‐induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway

To explore the underlying mechanism of lncRNA MALAT1 in the pathogenesis of diabetic cardiomyopathy (DCM). DCM models were confirmed in db/db mice. MiRNAs in myocardium were detected by miRNA sequencing. The interactions of miR‐185‐5p with MALAT1 and RhoA were validated by dual‐luciferase reporter a...

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Detalles Bibliográficos
Autores principales: Wang, Ting, Li, Na, Yuan, Lingling, Zhao, Mengnan, Li, Guizhi, Chen, Yanxia, Zhou, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468660/
https://www.ncbi.nlm.nih.gov/pubmed/37395157
http://dx.doi.org/10.1111/jcmm.17835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468660/
https://www.ncbi.nlm.nih.gov/pubmed/37395157
http://dx.doi.org/10.1111/jcmm.17835

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